Clinical Trial

UK Heart Failure With Preserved Ejection Fraction

Study acronym: UK HFpEF
Recruiting
View on ClinicalTrials.gov →
Summary
Heart failure occurs when the heart is no longer able to pump blood around the body properly. It can cause breathlessness, swollen feet and ankles, and tiredness. In about half of patients with heart failure, one measure of the heart's pumping function, called the 'ejection fraction', is normal. This type of heart failure is called heart failure with preserved ejection fraction, or HFpEF. HFpEF remains poorly understood. It is not clear why some people develop HFpEF, or what determines the severity of the condition. Treatment options may be limited. UK HFpEF is a study that aims to gain a better understanding of why people develop HFpEF, develop better tests to diagnosis it, identify and test new treatments, and follow the health of the people taking part over many years.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2022-06-28; most recent amendment 2025-05-01.
Status change: Not Yet Recruiting → Recruiting 2022-10-31
Trial Details
NCT Number NCT05441839
Lead Sponsor Manchester University NHS Foundation Trust
Collaborators: Pumping Marvellous Foundation, British Society for Heart Failure, National Institute for Health Research, United Kingdom, British Heart Foundation Data Science Centre
Conditions Heart Failure With Preserved Ejection Fraction (HFpEF)
Enrollment 10,000 participants
Start Date 2022-10-07
Primary Completion 2037-06-01 (estimated)
Study Completion 2037-06-01 (estimated)
Updated on ClinicalTrials.gov 2025-05-06