Clinical Trial

Influence of SRP With MM on the Composition and Functional Characteristics of Subgingival Microbiome Communities

Active, Not Recruiting
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Record status
This record was last updated July 22, 2025 (before its estimated December 2025 completion). Its status may not reflect the trial's current state.
Summary
The purpose of this study is to characterize the effect of minocycline microspheres (MM) administered as an adjunct to scaling and rooting planning (SRP) on the subgingival community composition and metatranscriptome functional profile, in comparison to a group treated with SRP only and to periodontally-healthy subjects.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2022-06-14; most recent amendment 2025-07-17.
Status change: Recruiting → Active, Not Recruiting 2025-07-17
Trial Details
NCT Number NCT05422742
Lead Sponsor West Virginia University
Collaborators: Bausch Health Americas, Inc.
Conditions Periodontitis
Enrollment 50 participants
Start Date 2021-10-15
Primary Completion 2025-12 (estimated)
Study Completion 2025-12 (estimated)
Updated on ClinicalTrials.gov 2025-07-22