Clinical Trial

Stereotactic Multiple Fraction Radiotherapy for Non-spine Bone Metastases

Study acronym: SMILE
Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated May 22, 2025 (before its estimated May 31, 2025 completion). Its status may not reflect the trial's current state.
Summary
To investigate, whether multi-fraction stereotactic body radiation therapy (SBRT) within 3 treatment fractions is non-inferior to the current standard of care of 5 fraction SBRT regarding pain response at 3 months after radiotherapy.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2022-06-01; most recent amendment 2025-05-19.
Status change: Active, Not Recruiting → Recruiting 2023-02-21
Status change: Not Yet Recruiting → Active, Not Recruiting 2022-08-16
Trial Details
NCT Number NCT05406063
Lead Sponsor Kantonsspital Winterthur KSW
Collaborators: Krebsforschung Schweiz, Bern, Switzerland
Conditions Radiation Therapy, Bone Metastases, Pain
Enrollment 162 participants
Start Date 2022-06-01
Primary Completion 2025-05-31 (estimated)
Study Completion 2026-05-31 (estimated)
Updated on ClinicalTrials.gov 2025-05-22