Transcranial Magnetic Stimulation (TMS) in the Treatment of Anorexia Nervosa

Anorexia nervosa is a severe psychiatric disorder associated with food avoidance and body image distortion, that is feeling fat despite being underweight. It is the third most common chronic illness among adolescent females, and its mortality reaches its peak between the ages 16 and 29 years old. There are very few treatments for anorexia nervosa and especially no biological treatments have been approved. Recent brain imaging research has repeatedly implicated brain circuits that include the insula in the disorder. The insula is a brain region important in taste processing as well as in the integration of body perception and has strong connections to the brain reward system. Transcranial magnetic stimulation (TMS) is a relatively new methodology that has been shown to alter neurocircuitry and alleviate depression. Here, the study goal is to develop TMS as a methodology to change altered neurocircuitry in anorexia nervosa and alleviate disorder specific behaviors.

NCT Number	NCT05368844
Lead Sponsor	University of California, San Diego
Conditions	Anorexia Nervosa
Enrollment	10 participants
Start Date	2022-06-16
Primary Completion	2026-03-11 (estimated)
Study Completion	2026-03-11 (estimated)
Updated on ClinicalTrials.gov	2026-08-03