Low Dose Naltrexone Use in Patients With POTS

Many patients with Postural Orthostatic Tachycardia Syndrome (POTS) experience debilitating fatigue and this significantly impacts their daily lives. Unfortunately, there are no treatments to help POTS patients with their fatigue. One medication, called low dose naltrexone (LDN), has been tested as a treatment for fatigue in other medical conditions. In this other research, LDN helped patients feel less fatigue. Other research studies have shown that LDN can help reduce markers of inflammation called cytokines. Reducing these cytokines could help reduce symptoms as well. There have been no research studies testing LDN in POTS to date. We are planning to do a research study to test LDN as a treatment to see if it helps POTS patients feel less fatigue.

NCT Number	NCT05363514
Lead Sponsor	University of Calgary
Conditions	Postural Orthostatic Tachycardia Syndrome
Enrollment	80 participants
Start Date	2026-07
Primary Completion	2029-06 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2026-05-01