Clinical Trial

Minds and Mentors Program- R33

Study acronym: MiMP
Active, Not Recruiting
View on ClinicalTrials.gov →
Summary
The proposed research effort will: The purpose of this study is as follows: 1. Test the effectiveness of the Minds and Mentors Program in a group treatment trial in which individuals using medications for opioid use disorder (MOUD) will be randomized in blocks of five to receive either the Minds and Mentors Program (n=120) or Twelve Step Facilitation (n=120). 2. Determine whether the MiMP: a) improves adherence to MOUD b) reduces the rate of relapse and cravings c) decreases self-reported anxiety, stress, and depression and d) reduces cortisol levels and cortisol reactivity to drug cues. 3. Examine whether pre-intervention cortisol reactivity is predictive of relapse outcomes, and/ or reductions in cortisol reactivity over the course of intervention mediate relapse outcomes.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2022-05-02; most recent amendment 2026-05-05.
Status change: Recruiting → Active, Not Recruiting 2026-05-05
Trial Details
NCT Number NCT05363371
Lead Sponsor University of Alabama, Tuscaloosa
Collaborators: University of Alabama at Birmingham, Tuscaloosa Veterans Affairs Medical Center, Pathway Healthcare, LLC
Conditions Opioid Use Disorder, Substance Use Disorders, Medication Assisted Treatment
Enrollment 240 participants
Start Date 2022-01-04
Primary Completion 2027-01-08 (estimated)
Study Completion 2027-05-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-06