2026-05-22
notable
Study Status, Contacts/Locations v17
Trial status changed: Active, Not Recruiting → Recruiting
Study sitesdetails revised at 1 of 1 site
2026-03-06
notable
Recruiting→Active, Not Recruiting Study Status, Contacts/Locations v16
Trial statusRecruiting→Active, Not Recruiting
Study sitesdetails revised at 1 of 1 site
Show 13 earlier versions
2025-09-24
minor
Study Status, Eligibility v13
Eligibility criteria-1 characters
[...] ng tumor as a product of longest perpendicular planes by MRI.
( or biopsy only subjects are not eligible for thistumor study)measuring less than 3cm x 3cm
Karnofsky Performance Status (KPS) of > 70%
CBC with differ [...]
2025-08-22
minor
Study Status, Contacts/Locations v12
Re-verified, no change to tracked fields
2025-06-23
minor
Study Status, Eligibility v11
Eligibility criteria-3 characters
[...] tumor must have a supratentorial component
CD70 positive (≥205%, 1+)
Tumor expression will be scored on a scale of 0 to 3 [...] el
= High level
The criteria for inclusion will be at least 205% of the cells scoring 1+ staining intensity (> 205%, 1+).
Surgical resection of tumors with less than 3cm x 3c [...]
2025-03-19
minor
Study Identification, Study Status, Sponsor/Collaborators, Study Description, Study Design, Eligibility, Contacts/Locations v10
Eligibility criteria+24 characters
Inclusion Criteria (Adult GBM):
Age ≥ 18 years
Newly-diagnosed de novo GBM based on the ab [...] ks following the last dose of study drug.
Exclusion Criteria (Adult GBM):
Prior invasive malignancy (except for non-melanomatous ski [...]
Collaborators2 to 1 entries
United States Department of Defense
Study title-26 characters
Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma (IMPACT)
2025-03-04
minor
3 amendments v7-v9
3 re-verifications since 2024-07-08, no change to tracked fields
2024-02-26
minor
Study Identification, Study Status, Study Description, Eligibility v6
Eligibility criteria+90 characters
[...] ot eligible)
The tumor must have a supratentorial component
MGMT-unmethylated
CD70 positive (≥20%, 1+)
Tumor expression will be scored on [...] ses detected below the tentorium or beyond the cranial vault
Leptomeningeal disease beyond the cranial vault.
(Focal, adjacent and leptomeningeal involvement is allowable at the discretion of the PI).
Recurrent or multifocal malignant gliomas.
The patient is [...]
Study description-22 characters
Newly diagnosed CD70 positive and MGMT-unmethylated adult GBM patients who have undergone surgery for maximal d [...]
Study title-22 characters
Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ and MGMT-unmethylated Adult Glioblastoma (IMPACT)
2024-01-08
minor
2 amendments v4-v5
2 re-verifications since 2023-08-24, no change to tracked fields
2023-07-25
notable
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v3
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2026-12→2027-12
Completion date2041-12→2042-12
Start date2023-07→2023-07-25
Study sitesdetails revised at 1 of 1 site
2023-05-15
minor
Study Status v2
Primary completion date2025-12→2026-12
Completion date2040-12→2041-12
Start date2022-10→2023-07
2022-07-29
minor
Study Identification, Study Status v1
Start date2022-06→2022-10
Study title+41 characters
Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ and MGMT-unmethylated Adult GBMGlioblastoma (IMPACT)