Clinical Trial

Psilocybin Therapy for Chronic Low Back Pain

Study acronym: POP
Active, Not Recruiting Phase 1/2
View on ClinicalTrials.gov →
Record status
This record was last updated April 29, 2026 (before its estimated July 2026 completion). Its status may not reflect the trial's current state.
Summary
This study evaluates whether psilocybin therapy helps patients cope with chronic low back pain more effectively. Patients may be recruited at Stanford and University of California San Francisco (UCSF), study procedures will occur at UCSF. Each participant will receive a dose of psilocybin with possibly one or more other drugs. Participants will undergo two preparation sessions, a dosing session, three integration sessions to discuss their psilocybin experience, and several follow up sessions.
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2022-04-22; most recent amendment 2026-04-23.
Status change: Recruiting → Active, Not Recruiting 2026-04-23
Status change: Not Yet Recruiting → Recruiting 2023-10-12
Trial Details
NCT Number NCT05351541
Lead Sponsor Joshua Woolley, MD, PhD
Conditions Chronic Low-back Pain
Enrollment 30 participants
Start Date 2023-12-01
Primary Completion 2026-07 (estimated)
Study Completion 2026-09 (estimated)
Updated on ClinicalTrials.gov 2026-04-29