Exercise Training and Fat Metabolism in Postmenopausal Women

Adipose tissue turnover plays a critical role in body weight maintenance, and obesity is underscored by the dysregulated balance between fat breakdown and synthesis. Although there are clear health-related benefits of physical activity, little is known about how resistance exercise, as opposed to endurance exercise, can reduce the risk of metabolic disorders, particularly in women. The goal of the proposed study is to investigate the effectiveness of resistance training to improve basal and stimulated fat metabolism in postmenopausal women with obesity and pre-diabetes, potentially serving as a viable and practical approach to prevent the onset of type 2 diabetes.

NCT Number	NCT05351476
Lead Sponsor	Florida State University Collaborators: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Pennington Biomedical Research Center, University of Arkansas
Conditions	Postmenopausal Symptoms, Obesity, Prediabetic State
Enrollment	120 participants
Start Date	2022-05-20
Primary Completion	2027-04-30 (estimated)
Study Completion	2027-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-04-13