Life After Sport: Prior Injury and Sedentary Behavior as Mechanisms of Later Poor Health

Competitive sport increases risk for musculoskeletal injury (e.g., traumatic knee injury) and may position former athletes for early onset of chronic diseases, chronic pain, poor health-related quality of life, and disability. Quantifying function in former athletes with and without a prior injury and non-athlete controls is critical to understanding long-term health trajectories in athletes and informing potential interventional studies. One modifiable factor that may be associated with long-term health in athletes is physical activity patterns. The purpose of this study is to evaluate strength, function, physical activity, dietary patterns, and cardiometabolic health among current and former competitive athletes and in nonathlete controls to evaluate the impact of prior knee injury and sedentary behavior as two potential determinants of later poor health and reduced function.

NCT Number	NCT05344001
Lead Sponsor	Marquette University Collaborators: National Institutes of Health (NIH)
Conditions	Aging, Athletic Injuries, Physical Inactivity, Knee Injuries and Disorders
Enrollment	450 participants
Start Date	2022-04-18
Primary Completion	2026-08 (estimated)
Study Completion	2027-08 (estimated)
Updated on ClinicalTrials.gov	2026-02-25