Clinical Trial

A Phase II Study of Pre-Op SRS Followed by Surgical Resection for Brain Metastases

Active, Not Recruiting
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Record status
This record was last updated March 5, 2025 (before its estimated November 2025 completion). Its status may not reflect the trial's current state.
Summary
This is a research study to determine if performing stereotactic radiosurgery (SRS) prior to surgical resection of the brain metastasis (tumor) will improve local control, in other words, increase the possibility of total removal of the primary tumor without local recurrence on longterm follow up. This research study will also determine if pre-operative SRS will lower the risk of radionecrosis that is the breakdown of body tissue at the original tumor site, and the development of leptomeningeal disease.
Protocol Amendment History 2 amendments
This ClinicalTrials.gov record has been amended 2 times since 2022-04-18; most recent amendment 2025-03-03.
Status change: Recruiting → Active, Not Recruiting 2025-03-03
Trial Details
NCT Number NCT05341739
Lead Sponsor Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute)
Collaborators: Elekta Limited
Conditions Brain Metastases, Adult
Enrollment 20 participants
Start Date 2021-12-14
Primary Completion 2025-11 (estimated)
Study Completion 2025-11 (estimated)
Updated on ClinicalTrials.gov 2025-03-05