Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT05337618 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Improving Neurotrauma by Depolarization Inhibition With Combination Therapy (INDICT)

Study acronym: INDICT
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated December 22, 2025 (before its estimated September 1, 2026 completion). Its status may not reflect the trial's current state.

Record History

  1. Primary completion date: Apr 1, 2026 to Sep 1, 2026 Completion date: Sep 20, 2026 to Mar 20, 2027v4 Show 1 more changeShow less
    • Completion date: Sep 20, 2026 to Mar 20, 2027
  2. Trial status: Not Yet Recruiting to Recruiting Primary completion date: Apr 2024 to Apr 1, 2026 · Completion date: Oct 2024 to Sep 20, 2026 · Start date changed from estimate of Sep 2022 to Dec 16, 2022 · 1 morev3 Show 4 more changesShow less
    • Primary completion date: Apr 2024 to Apr 1, 2026
    • Completion date: Oct 2024 to Sep 20, 2026
    • Start date changed from estimate of Sep 2022 to Dec 16, 2022
    • Site details revised
  3. Start date: May 2022 to Sep 2022v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This study is a randomized Phase 2 trial to determine the feasibility of real-time electrocorticographic monitoring of spreading depolarizations (SD) to guide implementation of a tier-based protocol of intensive care therapies, aimed at SD suppression, for the management of patients who have undergone acute operative treatment of severe traumatic brain injury.
Trial Details
NCT Number NCT05337618
Lead Sponsor University of Cincinnati
Collaborators: University of New Mexico, University of Pennsylvania
Conditions Traumatic Brain Injury
Enrollment 72 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov