Does Additional Use of Preoperative Azithromycin Decrease Posthysterectomy Infections

During hysterectomy bacteria may enter into the peritoneal cavity through vaginal opening and contaminate the healing tissues. The risk for deep infection after hysterectomy is about 5%. By reducing post-hysterectomy infections, it is possible to reduce individual burden of disease in addition to the direct and indirect financial costs. This study primary aim is to assess if prophylactic preoperative use of azithromycin in addition to generally used cefuroxime decreases post-hysterectomy infections as compared to cefuroxime only prophylaxis during 30 days after hysterectomy. Secondary aim is to assess if there is change in post-hysterectomy superficial infections, urinary tract infections, or post-operative fever between the cohorts and to report possible side-effects of the used antibiotics. In addition, the study finds out a possible role of bacterial vaginosis and microbiome n post-hysterectomy infections.

NCT Number	NCT05337566
Lead Sponsor	Helsinki University Central Hospital Collaborators: University of Turku, Tampere University Hospital, Kuopio University Hospital, Oulu University Hospital, Jyväskylä Central Hospital
Conditions	Infection Post Op, Hysterectomy, Antibiotics, Prophylactic
Enrollment	2,278 participants
Start Date	2022-09-05
Primary Completion	2025-12 (estimated)
Study Completion	2030-12 (estimated)
Updated on ClinicalTrials.gov	2024-08-21