Clinical Trial

Non-Nutritive Sweetener Consumption and Glucose Homeostasis in Older Adults With Prediabetes

Recruiting
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Record status
This record was last updated December 4, 2025 (before its estimated February 28, 2026 completion). Its status may not reflect the trial's current state.
Summary
Animal and observational research in humans suggest that specific types of non-nutritive sweeteners (NNS) may impair glycemic control. However, whether NNS consumption impacts glucose homeostasis in middle-aged/older adults with prediabetes is unknown, and potential mechanisms by which this could occur have yet to be identified. The overall objective of this R21 proposal is to establish proof-of-concept for alterations in glucose homeostasis following intake of sucralose, but not aspartame, in middle-aged/older adults with prediabetes compared to a eucaloric diet with no NNS.
Protocol Amendment History 9 amendments
This ClinicalTrials.gov record has been amended 9 times since 2022-04-19; most recent amendment 2025-12-03.
Status change: Not Yet Recruiting → Recruiting 2022-06-28
Trial Details
NCT Number NCT05337098
Lead Sponsor Virginia Polytechnic Institute and State University
Conditions Continuous Glucose Monitoring, Oral Glucose Tolerance, Insulin Sensitivity, Inflammatory Markers
Enrollment 30 participants
Start Date 2023-04-18
Primary Completion 2026-02-28 (estimated)
Study Completion 2026-02-28 (estimated)
Updated on ClinicalTrials.gov 2025-12-04