Clinical Trial

LOng COvid COmorbidities: Endocrine,Metabolic,Neuropsychiatric,Muscle,Cardiovascular,Pulmonary,Dermatologic Dysfunctions

Study acronym: LO-COCO
Recruiting
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Record status
This record was last updated August 8, 2025 (before its estimated January 27, 2026 completion). Its status may not reflect the trial's current state.
Summary
Considering the compelling amount of studies focused on patients in the active phase of COVID-19 disease and the scarcity of studies focused on patient cured from disease aimed at evaluating the sequelae of SARS-CoV-2 infection, the purpose of the study is to investigate whether in patients recovered from COVID-19 disease, SARS-CoV-2 infection has induced: 1) endocrine-metabolic function damage; 2) neuro-psychiatric damage; 3) muscle damage; 4) pulmonary damage; 5) cardiological damage; 6) venous vascular damage; 7) dermatological damage. Patients will be evaluated at baseline (at discharge from infectious and/or pneumology unit) and after 3- 12 months. A better definition of the prevalence and type of sequelae after recovery from COVID-19 disease could significantly improve the therapeutic management and long-term follow-up of these patients, with a relevant impact in terms of health resources and public health.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2022-03-19; most recent amendment 2025-08-07.
Trial Details
NCT Number NCT05293366
Lead Sponsor Federico II University
Collaborators: Azienda Sanitaria Locale Napoli 2 Nord
Conditions Long Covid-19
Enrollment 100 participants
Start Date 2022-01-27
Primary Completion 2026-01-27 (estimated)
Study Completion 2027-01-27 (estimated)
Updated on ClinicalTrials.gov 2025-08-08