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Ketorolac in Upper Extremity Tendinopathy and Arthropathy

StatusRecruiting
PhasePhase 4
Started2023-01-31
View on ClinicalTrials.gov ↗

Amendment history

2026-09-01
minor
Study Identification, Study Status, Oversight v9
Re-verified, no change to tracked fields
2025-08-19
minor
Study Status v8
Primary completion date2025-07→2027-07
Completion date2025-10→2027-07
2025-03-31
minor
Study Status, Oversight, Contacts/Locations v7
Study sitescontacts updated at 3 of 4 sites
2024-03-25
minor
Study Status v6
Re-verified, no change to tracked fields
2023-03-23
minor
Study Identification, Study Status, Sponsor/Collaborators v5
Collaborators1 entry, revised
American Association for Hand Surgery: AAHS
Study title+22 characters
Ketorolac Randomizedin ClinicalUpper TrialExtremity Tendinopathy and Arthropathy
Show 4 earlier versions
2023-03-20
notable
Not Yet Recruiting→Recruiting Study Identification, Study Status, Sponsor/Collaborators, Study Description, Conditions, Arms and Interventions, Eligibility, Contacts/Locations v4
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2023-02→confirmed 2023-01-31
InterventionsKetorolac injection to the hand or wrist (Drug), Triamcinolone injection to the hand or wrist (Drug)→Ketorolac injection to the shoulder, elbow, wrist, or hand (Drug), Triamcinolone injection to the shoulder, elbow, wrist, or hand (Drug)
Eligibility criteria+18 characters
Inclusion Criteria: Age 18 or older, symptomatic tendinopathy or arthropathy of the shoulder, elbow, hand, or wrist who have not undergone prior surgical treatment fo [...]
Study description+52 characters
Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the handupper and wristextremity are common yet disabling diseases. These pathologic process [...] progressive and painful leading to significant impairments onin quality of life. Diagnosed patients experience a profound r [...] vities of daily living. For a majority of the aforementioned shoulder, elbow, and hand/wrist arthropathies and tendinopathies, no curative tr [...] arge joint OA, however, fewer studies with mixed results on the duration of symptomatic relief exist for OA or tendinopathy of the smaller structures of the hand/wris [...] [...]
Study sitesdetails revised at 4 of 4 sites
Study title-21 characters
Ketorolac inRandomized HandClinical and Wrist Tendinopathy and ArthropathyTrial
2022-11-29
minor
Study Status, Sponsor/Collaborators, Conditions, Outcome Measures, Eligibility v3
Start date2022-11→2023-02
Secondary endpoints+231 characters
Changes in the patient-Reported Outcomes Measurement Information System (PROMIS) Changes in Hand subjectivity value Changes in the quick disabilities-arm-shoulder-hand (DASH) assessment Changes in Grip Strength Changes in Key Pinch
Primary endpoints6 to 1 entries
Changes in Grip Strength Changes in Hand subjectivity value Changes in Key Pinch Changes in the patient-Reported Outcomes Measurement Information System (PROMIS) Changes in the quick disabilities-arm-shoulder-hand (DASH) assessment
Collaborators+37 characters
American Association for Hand Surgery
2022-09-29
minor
Study Status v2
Primary completion date2024-12→2025-07
Completion date2025-03→2025-10
Start date2022-07→2022-11
2022-05-17
minor
Study Status v1
Primary completion date2024-04→2024-12
Completion date2024-12→2025-03
Start date2022-04→2022-07
2022-03-15
minor
Original filing
Osteoarthritis (OA) and inflammatory conditions of the tendons and joints of the shoulder, elbow, hand, and wrist are common yet disabling diseases. Standard management utilizes conservative measures to minimize pain and improve function. Conservative pharmacological management commonly includes corticosteroid and ketorolac injections which have been well investigated as a modality of pain control and improved function in large joint OA. However, fewer studies yielding mixed results on the duration of symptomatic relief exist for arthropathy and tendinopathy of these joints. The goal of this study is to evaluate the efficacy of ketorolac and triamcinolone injections for common shoulder, elbow, wrist, and hand tendinopathy or arthropathy. Participants will be blinded to the treatment received. The duration of an individual participant's participation in this study is 24 weeks. During this time period, patients will be asked to return to the clinic for an in-person follow-up 6 weeks after the injection with either ketorolac or triamcinolone) in order to assess participants' outcomes. All work related to this project will take place at the Emory Sports Medicine Complex, Emory Executive Park, Emory Musculoskeletal Institute, the Emory University Orthopaedic and Spine Hospital, and the Emory Saint Joseph's Hospital. This study will add to existing knowledge by providing further insight into how wrist arthropathy should be most optimally and conservatively managed.
Trial Details
NCT Number NCT05292339
Lead Sponsor Emory University
Collaborators: American Association for Hand Surgery: AAHS
Conditions Osteoarthritis, Tendinopathy, Arthropathy
Enrollment 160 participants
Start Date 2023-01-31
Primary Completion 2027-07 (estimated)
Study Completion 2027-07 (estimated)
Updated on ClinicalTrials.gov 2026-09-03