Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT05289661 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Descemet Endothelial Thickness Comparison Trial I

Study acronym: DETECT I
StatusActive, Not Recruiting
PhasePhase 3
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. 2 versions Re-verified since May 6, 2026, no change to tracked fieldsv11-v12
  2. Trial status: Recruiting to Active, Not Recruiting
    • Primary completion date: Oct 31, 2026 to Nov 30, 2026
    • Site details revised at 7 of 7 sites
    v10
  3. Primary completion date: Jul 31, 2026 to Oct 31, 2026
    • Study completion date: Aug 31, 2027 to Nov 30, 2027
    • Site contacts updated at 3 of 7 sites
    v9
  4. Primary completion date: Mar 31, 2026 to Jul 31, 2026v8 Show 4 more changesShow less
    • Study completion date: Mar 31, 2027 to Aug 31, 2027
    • Eligibility criteria shortened, about 40 words
    • Site details revised at 4 of 7 sites
    • Collaborators: 6 to 8
  5. Study sites: 4 to 7v7
Show 5 earlier versionsHide 5 earlier versions
  1. Primary completion date: Sep 30, 2025 to Mar 31, 2026
    • Study completion date: Sep 30, 2026 to Mar 31, 2027
    v6
  2. Study completion date: Jun 30, 2026 to Sep 30, 2026
    • Eligibility criteria shortened, about 41 words
    v5
  3. Trial status: Not Yet Recruiting to Recruiting
    • Study sites: 0 to 4
    • Start date changed from estimate of Jul 1, 2022 to Jul 15, 2022
    v4
  4. Primary completion date: Mar 31, 2025 to Sep 30, 2025
    • Start date: May 31, 2022 to Jul 1, 2022
    • Study completion date: Feb 28, 2026 to Jun 30, 2026
    • Collaborators revised (6)
    v3
  5. Start date: Apr 1, 2022 to May 31, 2022v2
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Descemet Endothelial Thickness Comparison Trial (DETECT) I is a multi-center, outcome assessor-masked, placebo-controlled clinical trial randomizing 160 patients in a 2x2 factorial design. The purpose of this study is to determine differences in visual outcomes between two types of corneal transplant surgeries, ultrathin Descemet stripping automated endothelial keratoplasty (UT-DSAEK) and Descemet membrane endothelial keratoplasty (DMEK), and to determine the effect of rho-kinase inhibitors on endothelial cell loss.
Trial Details
NCT Number NCT05289661
Lead Sponsor Stanford University
Collaborators: Oregon Health and Science University, University of California, San Francisco, University of California, Davis, Case Western Reserve University, Dartmouth-Hitchcock Medical Center, University of Pennsylvania, University of Miami, Wills Eye Hospital
Conditions
(from sponsor)		 Fuchs
Enrollment 160 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov