Clinical Trial

Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation

Study acronym: OPIF
Active, Not Recruiting
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Summary
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs. saline solution (NaCl) injection (Placebo) transvaginally or laparoscopically for follicular activation in patients with child wish and with low ovarian reserve/expected poor ovarian response planning to undergo IVF or ICSI using own eggs. Pain score as numerical rating score and validated quality of life questionnaire will be requested after the procedure. Longterm follow-up of all participants will be performed 1, 2 and 5 years after end of study.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2022-03-06; most recent amendment 2025-05-29.
Status change: Recruiting → Active, Not Recruiting 2025-05-29
Status change: Not Yet Recruiting → Recruiting 2022-03-25
Trial Details
NCT Number NCT05279560
Lead Sponsor University of Luebeck
Conditions Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
Enrollment 114 participants
Start Date 2022-03-17
Primary Completion 2025-04-30 (estimated)
Study Completion 2030-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-06-04