Glycemic Variations During the Menstrual Cycle in Women With Type 1 Diabetes

In clinical practice, women living with type 1 diabetes frequently report that insulin requirements change across the menstrual cycle. Consequently, glycemic fluctuations are observed. This phenomenon could be explained by a decrease in insulin sensitivity during the second half of the menstrual cycle (luteal phase). Overall, despite an important proportion of women reporting glycemic and/or insulin variations across the menstrual cycle, studies to date have involved small sample sizes, and have had inconsistent results. The objective of this study will be to study glycemic fluctuations across the menstrual cycle using CGM data, alongside insulin data, in a large sample of women.

NCT Number	NCT05258292
Lead Sponsor	Institut de Recherches Cliniques de Montreal
Conditions	Type1diabetes
Enrollment	86 participants
Start Date	2022-05-02
Primary Completion	2026-04-01 (estimated)
Study Completion	2026-05-31 (estimated)
Updated on ClinicalTrials.gov	2026-03-05