Clinical Trial

Plasma Trimethylamine N-oxide Elevation Induced by L-carnitine Supplementation and Insulin Resistance

Study acronym: MR
Active, Not Recruiting
View on ClinicalTrials.gov →
Record status
This record was last updated October 3, 2025 (before its estimated May 31, 2026 completion). Its status may not reflect the trial's current state.
Summary
The primary aims of the current study: * using L-carnitine supplementation modulate the level of plasma trimethylamine N-oxide to assess its effect on circulating cytokines related to diabetes and metabolic syndrome; * using simulated night-shift work intervention as a stress factor, explore the effect of circulating metabolites on insulin sensitivity The secondary aim is to evaluate the effect of carnitine supplementation on gut microbiome composition.
Protocol Amendment History 6 amendments
This ClinicalTrials.gov record has been amended 6 times since 2022-02-11; most recent amendment 2025-09-29.
Status change: Suspended → Active, Not Recruiting 2025-03-19
Status change: Enrolling by Invitation → Suspended 2023-11-14
Status change: Recruiting → Enrolling by Invitation 2022-02-21
Trial Details
NCT Number NCT05251207
Lead Sponsor Poznan University of Physical Education
Conditions Insulin Resistance
Enrollment 40 participants
Start Date 2022-02-07
Primary Completion 2026-05-31 (estimated)
Study Completion 2027-05-31 (estimated)
Updated on ClinicalTrials.gov 2025-10-03