Clinical Trial

Electronic Cigarette-derived Oxidants and Cardiopulmonary Effects

Active, Not Recruiting Early Phase 1
View on ClinicalTrials.gov →
Summary
This is a pilot study on the impact of switching from cigarettes to Electronic Cigarettes (EC) on disease-related clinical symptoms and biomarkers of harm in smokers with preexisting Chronic Obstructive Pulmonary Disease (COPD). The researchers hypothesize that the smokers who switch to EC completely or significantly will experience reduced COPD symptoms, risks of exacerbations, and decreased levels of oxidative stress and inflammation.
Protocol Amendment History 13 amendments
This ClinicalTrials.gov record has been amended 13 times since 2022-02-04; most recent amendment 2025-10-23.
Status change: Recruiting → Active, Not Recruiting 2025-10-23
Status change: Not Yet Recruiting → Recruiting 2022-09-02
Trial Details
NCT Number NCT05239793
Lead Sponsor Milton S. Hershey Medical Center
Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions Chronic Obstructive Pulmonary Disease
Enrollment 30 participants
Start Date 2022-11-22
Primary Completion 2025-06-30 (estimated)
Study Completion 2026-06-30 (estimated)
Updated on ClinicalTrials.gov 2025-10-27