A Randomized Trial of Imaging Selection Modalities for Stroke Thrombectomy (NO-SELECT)

Several studies suggest that advanced multi-modal imaging with CTP should be used to screen late time window stroke patients for thrombectomy. However, NCCT is more accessible when comparing with CTP. It is unclear whether the NCCT-based ASPECTS can be used as an imaging criterion to screen patients for thrombectomy. The newly published MR CLEAN-LATE and TENSION trials used NCCT or CTA, but still relied on ASPECTS scores to evaluate and select patients for endovascular therapy. However, different trials have different time windows. The aim of this trial was to assess the clinical outcomes of stroke patients with anterior large vessel occlusion who selected by simple imaging (NCCT) comparing via standard imaging screening strategy (CTP/MRI). The hypothesis is that simple imaging is non-inferior to standard imaging selection strategy in terms of achieving favorable outcomes.

NCT Number	NCT05230914
Lead Sponsor	Xinqiao Hospital of Chongqing Collaborators: The First Affiliated Hospital of Hainan Medical University, Dalian Central Hospital, Huai'an First People's Hospital
Conditions	Stroke, Ischemic, Stroke, Acute
Enrollment	1,846 participants
Start Date	2024-12-12
Primary Completion	2027-06-30 (estimated)
Study Completion	2027-10-31 (estimated)
Updated on ClinicalTrials.gov	2025-12-26