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Interpretation Bias as a Mechanism of Treatment Response in OCD

StatusRecruiting
PhaseNot applicable
Started2022-03-30
View on ClinicalTrials.gov ↗
Record status
This record was last updated May 18, 2026 (before its estimated August 31, 2026 completion). Its status may not reflect the trial's current state.

Amendment history

2026-05-15
3 amendments v5-v7
3 re-verifications since 2024-03-11, no change to tracked fields
2022-12-30
Study Status v4
Start date2022-04-01→2022-03-30
2022-12-23
Study Status, Eligibility v3
Primary completion date2025-03→2026-08-31
Completion date2026-08→2026-08-31
Start date2022-03-24→2022-04-01
Eligibility criteria-55 characters
[...] a: 1) Currently experiencing acute symptoms of psychosis 2) psychotic/autism spectrumPsychotic disorder diagnosis 3) history of a traumatic brain injury
2022-04-07
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Start dateestimated 2022-03→confirmed 2022-03-24
Study sites0→1
2022-02-03
Study Status, Eligibility v1
Eligibility criteria-16 characters
Inclusion Criteria: 1) OCD Institute patients, 2) adults (> 18 years old), 3) able to complete a computer task for 20 minutes, and 4) consent to main OCD Institute study protocol; 5) primary diagnosis of OCD (as measured by a score of >16 [...] BOCS and a clinical diagnosis of OCD by their treatment team, and 6) score of >131 on the Obsessive Beliefs Questionnaire-44 [...] by the Obsessive Compulsive Cognitions Working Group (2005)]. Exclusion Criteria: 1) Currently experiencing acute symptoms of psychosis; 2) psychotic/autism spectrum disorder diagnosis; 3) history of a traumatic brain injury
2022-01-25
Original filing
Mclean Hospital
53 trials monitored
See 1 trial at risk
This study will conduct a randomized controlled trial of Cognitive Bias Modification for Interpretation (CBM-I) as an augmentation to treatment as usual for obsessive compulsive disorder (OCD). CBM-I is a digital intervention designed to directly manipulate interpretation bias through repeated practice on a training task, thereby inducing cognitive changes in a relatively automatic or implicit manner. Specifically, this study will examine the feasibility, acceptability, and clinical outcomes associated with CBM-I. Adults with obsessive compulsive disorder (OCD) will be recruited from a treatment program for this disorder and participants will be randomly assigned to either receive: 1) up to 12 sessions of CBM-I, or or up to 12 sessions of psychoeducation as a control condition.
Trial Details
NCT Number NCT05224414
Lead Sponsor Mclean Hospital
Conditions Obsessive-Compulsive Disorder
Enrollment 106 participants
Start Date 2022-03-30
Primary Completion 2026-08-31 (estimated)
Study Completion 2026-08-31 (estimated)
Updated on ClinicalTrials.gov 2026-05-18