Clinical Trial

WithHolding Enteral Feeds Around Blood Transfusion (International)

Study acronym: WHEAT
Recruiting
View on ClinicalTrials.gov →
Summary
The WHEAT International trial is a comparative effectiveness trial exploring whether withholding enteral feeds around the time of blood transfusion in very premature infants (\<30 weeks) will reduce the occurrence of Necrotizing Enterocolitis (NEC). Currently both continued feeding and withholding feeding are approved care practices. The current study will randomize infants from Neonatal Intensive Care Units (NICUs) across Canada and the United Kingdom (UK) into one of the two care approaches (withholding or continued feeds) to determine if any significant outcomes are found.
Protocol Amendment History 5 amendments
This ClinicalTrials.gov record has been amended 5 times since 2022-01-17; most recent amendment 2026-04-21.
Status change: Not Yet Recruiting → Recruiting 2022-03-31
Trial Details
NCT Number NCT05213806
Lead Sponsor IWK Health Centre
Collaborators: Canadian Institutes of Health Research (CIHR), Imperial College London
Conditions Necrotizing Enterocolitis
Enrollment 4,333 participants
Start Date 2022-01-28
Primary Completion 2027-03-31 (estimated)
Study Completion 2027-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-04-24