Track this trial free. DataLookout checks ClinicalTrials.gov daily and emails you which fields changed on NCT05211661 (status, enrollment, completion dates, endpoints, sites) when this record is updated. Free accounts track up to 5 trials.

Track this trial

Diaphragm Atrophy and Dysfunction in Mechanical Ventilation

Study acronym: DAM
StatusRecruiting
PhaseNot specified
Started
View on ClinicalTrials.gov ↗

Record History

See every version on ClinicalTrials.gov ↗

  1. Enrollment increased: 15 → 20 participants
    • Eligibility criteria expanded, about 19 words
    • Publications: details revised at 6 of 6 entries
  2. Primary completion date: Dec 1, 2023 to May 1, 2028
    • Study completion date: Dec 1, 2023 to Jun 1, 2028
    v4
  3. Start date changed from estimate of May 10, 2022 to Oct 10, 2022v3
  4. Trial status: Not Yet Recruiting to Recruiting
    • Start date: Mar 1, 2022 to May 10, 2022
    • Site details revised
    v2
  5. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The gold standard of twitch transdiaphragmatic pressure recordings would ultimately clear the fog around the rate of development of Ventilator induced Diaphragm Dysfunction (VIDD) in mechanically ventilated patients over time. Through measurements made even after mechanical ventilation (MV) it could be clarified to what extent patients recover from VIDD. Paired with cortical stimulation and electromyographic recordings of diaphragm muscle potentials, it could be explored to what extent decreased diaphragm excitability due to long term MV contributes to VIDD on the level of motor cortex. Against that background the present project aims at determining the rate of decline in diaphragm function, strength and control in patients undergoing MV (including measurements after extubation).
Trial Details
NCT Number NCT05211661
Lead Sponsor RWTH Aachen University
Conditions
(from sponsor)		 Diaphragm Issues, Mechanical Ventilation Complication, Respiratory Failure, Intensive Care (ICU) Myopathy
Related terms Muscular Diseases, Respiratory Insufficiency
Enrollment 20 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov