Taxifolin/Ergothioneine and Immune Biomarkers in Healthy Volunteers (TaxEr)

The complexities of the immune system make measuring the impact of dietary interventions upon its function challenging. The immune system is highly responsive to environmental influences, including the diet. An individual's diet provides the energy required to mount a strong and protective immune response, the building blocks required for synthesis of immune mediators such as antibodies and cytokines, and can also indirectly affect immune function via changes in the gut microbiome. Immune function varies across the lifecourse, with a well understood decline in immune function with age, resulting in impaired vaccination responses and an increased risk of infections and of severe complications and mortality arising from common communicable diseases such as influenza. This impaired immunity with ageing is known as immunosenescence and this affects both innate and acquired arms of the immune system.

NCT Number	NCT05190432
Lead Sponsor	University of Southampton Collaborators: Blue California
Conditions	Antioxidative Stress, Cold, Influenza, Aging, Inflammation
Enrollment	90 participants
Start Date	2021-11-10
Primary Completion	2022-09-29 (estimated)
Study Completion	2026-07 (estimated)
Updated on ClinicalTrials.gov	2026-05-13