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Effects of Microencapsulated Propolis and Turmeric in Patients With Chronic Kidney Disease

StatusActive, Not Recruiting
PhaseNot applicable
Started
View on ClinicalTrials.gov ↗

Record History

  1. Study completion date: Dec 31, 2024 to Dec 31, 2026v4
  2. Primary completion date: Dec 2022 to Dec 1, 2024
    • Study completion date: Dec 2022 to Dec 31, 2024
    v3
  3. Trial status: Not Yet Recruiting to Active, Not Recruiting
    • Start date changed from estimate of Feb 2022 to Mar 7, 2022
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Oxidative stress and inflammation are correlated with Chronic Kidney Disease (CKD), in a way that they bring several harms to patients, including an increased risk of cardiovascular disease and mortality. Adjuvant therapeutic options such as bioactive compounds present in some foods seem to mitigate inflammation. Turmeric and propolis are foods that have compounds with antioxidant and anti-inflammatory capacity, as they promote the activation of nuclear erythroid transcription factor 2 (Nrf2 - responsible for the synthesis of antioxidant enzymes) and inhibit the activity of nuclear factor Kappa B (NF-κB - which increases the synthesis of inflammatory cytokines). This work aims to evaluate the effects of supplementation of associated propolis and turmeric microcapsules on inflammatory markers in patients with CKD undergoing hemodialysis (HD).
Trial Details
NCT Number NCT05183737
Lead Sponsor Universidade Federal Fluminense
Conditions
(from sponsor)		 Chronic Kidney Diseases, Inflammation
Related terms Inflammation, Renal Insufficiency, Chronic
Enrollment 34 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov