STREAM Trial - Statins in Multimorbid Older Adults Without Cardiovascular Disease

Statins are among the most widely used drugs. While they were found to be effective for primary and secondary prevention of cardiovascular disease (CVD) in middle-aged subjects, their benefits for primary prevention in older adults (aged ≥70 years) without CVD are uncertain, particularly for those with multimorbidity. The aim of this randomized controlled trial (RCT) is to provide guidance on the benefits and risks of statin deprescribing in multimorbid older adults.

NCT Number	NCT05178420
Lead Sponsor	Insel Gruppe AG, University Hospital Bern Collaborators: University of Bern
Conditions	Statin Treatment for Primary Prevention
Enrollment	1,880 participants
Start Date	2021-11-16
Primary Completion	2026-04-30 (estimated)
Study Completion	2026-04-30 (estimated)
Updated on ClinicalTrials.gov	2026-08-13