Clinical Trial

EndotyPIng PreHospitAl de Novo Acute hYpoxemic Respiratory Failure

Study acronym: EPIPHANY
Recruiting
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Record status
This record was last updated August 7, 2025 (before its estimated March 25, 2026 completion). Its status may not reflect the trial's current state.
Summary
We attempt to perform dynamic endotyping of critically ill patients presenting in the emergency department with de novo acute hypoxemic respiratory failure (AHRF). We also attempt to identify what clinical, radiological, physiological and biological variables collected early in the course of AHRF correlate with subsequent mortality and/or persistent severe hypoxemia.
Protocol Amendment History 4 amendments
This ClinicalTrials.gov record has been amended 4 times since 2021-12-03; most recent amendment 2025-08-04.
Status change: Not Yet Recruiting → Recruiting 2022-07-10
Trial Details
NCT Number NCT05150483
Lead Sponsor Evangelismos Hospital
Conditions Acute Hypoxemic Respiratory Failure, Acute Respiratory Distress Syndrome
Enrollment 250 participants
Start Date 2021-12-10
Primary Completion 2026-03-25 (estimated)
Study Completion 2026-04-30 (estimated)
Updated on ClinicalTrials.gov 2025-08-07