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Stress and Opioid Misuse Risk: The Role of Endogenous Opioid and Endocannabinoid Mechanisms

StatusCompleted
PhasePhase 4
Started2022-03-02
View on ClinicalTrials.gov ↗

Amendment history

2026-09-01
Study Status, Oversight, Study Design, Contacts/Locations, Document Section v7
Trial completed
Phase changed: not applicable → Phase 4
Final enrollment: 101 participants (planned 120)
Primary completion confirmed: February 2026 (last estimated July 2026)
Primary completion dateestimated 2026-07-31→confirmed 2026-02-16
Completion dateestimated 2026-07-31→confirmed 2026-04-07
Enrollment targetestimated 120→confirmed 101
Study sitesdetails revised at 1 of 1 site
2025-10-20
Study Status v6
Primary completion date2026-03-24→2026-07-31
Completion date2026-03-24→2026-07-31
2024-10-07
2 amendments v4-v5
2 re-verifications since 2023-10-02, no change to tracked fields
2023-02-10
Study Status v3
Primary completion date2026-03→2026-03-24
Completion date2026-03→2026-03-24
2022-03-04
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2026-01→2026-03
Completion date2026-01→2026-03
Start dateestimated 2022-01→confirmed 2022-03-02
Study sitesdetails revised at 1 of 1 site
2021-12-08
Study Status v1
Primary completion date2026-12→2026-01
Completion date2026-12→2026-01
Start date2021-12→2022-01
2021-11-19
Original filing
The purpose of this study is to see how stress influences the effects of opioid pain medications often used to help relieve back pain. The study will help to learn more about how high stress levels could increase risk for pain medication misuse.
Trial Details
NCT Number NCT05142267
Lead Sponsor Vanderbilt University Medical Center
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Opioid Use Disorder, Back Pain, Stress
Enrollment 101 participants
Start Date 2022-03-02
Primary Completion 2026-02-16 (estimated)
Study Completion 2026-04-07 (estimated)
Updated on ClinicalTrials.gov 2026-09-04