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RVF and Other Emerging Infectious Diseases in East and Central Africa

StatusRecruiting
PhaseNot specified
Started
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Record History

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  1. Primary completion date: Dec 31, 2025 to May 31, 2027v2 Show 4 more changesShow less
    • Start date: Oct 8, 2021 to Feb 1, 2025
    • Study completion date: Dec 31, 2025 to Dec 31, 2027
    • Site details revised at 2 of 10 sites
    • Collaborators: 17 to 16
  2. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Rift Valley fever (RVF), a disease transmitted from livestock (cattle, sheep, goats, camels) to humans more commonly occurs in the East and Central Africa (ECA) regions where more than 15 major epidemics affecting more than one country have been reported over the past 50 years. Within the region, there are specific areas, referred to as hotspots, which support RVF virus maintenance via low-level virus circulation between animals, humans, and mosquitoes. Most outbreaks originate from these hotspots. Our goal is to conduct studies in RVF hotspots in four ECA countries, Kenya, Uganda, Tanzania, and Democratic Republic of Congo (DRC) to determine the burden of RVF disease among humans, wildlife and livestock during inter-epidemic periods (IEPs) and discover circulation of undetected infectious diseases. This information is important for use in developing an early warning system and possibly a vaccination strategy. The study will take place in Uganda, Kenya, Tanzania and Democratic Republic of Congo
Trial Details
NCT Number NCT05139524
Lead Sponsor Washington State University
Collaborators: National Institute of Allergy and Infectious Diseases (NIAID), Emory University, Washington University School of Medicine, Kenya Medical Research Institute, University of Nairobi, The International Livestock Research Institute (ILRI), MRC/UVRI and LSHTM Uganda Research Unit, Sokoine University of Agriculture, Institut National de Recherche Biomedicale (INRB), Institute of Tropical Medicine, Belgium, Charite University, Berlin, Germany, Kenya Ministry of Health, Ministry of Agriculture Livestock Fisheries and Cooperatives, Kenya, Ministry of Agriculture, Animal Industry and Fisheries, Uganda, Ministry of Health, Uganda, Ministry of Public Health, Democratic Republic of the Congo
Conditions
(from sponsor)		 Rift Valley Fever, Hemorrhagic Fevers, Viral
Related terms Communicable Diseases, Emerging, Hemorrhagic Fevers, Viral, Rift Valley Fever
Enrollment 5,000 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov