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Use of Beetroot Juice to Protect Against Postoperative Ileus Following Colorectal Surgery: BEET IT Study

Study acronym: BEET IT
StatusRecruiting
PhasePhase 2
Started
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Record status
This record was last updated February 10, 2026 (before its estimated September 30, 2026 completion). Its status may not reflect the trial's current state.

Record History

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  1. Primary completion date: Dec 31, 2024 to Sep 30, 2026
    • Study sites: 5 to 6
    • Study completion date: Jun 30, 2025 to Dec 30, 2027
    v5
  2. 2 versions Re-verified since Oct 20, 2023, no change to tracked fieldsv3-v4
  3. Study sites: 4 to 5
    • Eligibility criteria expanded, about 22 words
    • Study description shortened, about 4 words
    v2
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The goal of the BEET IT study is to examine if preoperative intake of beetroot juice can ameliorate gastrointestinal (GI) recovery after colorectal surgery and thereby help to reduce the duration of postoperative ileus (POI) and prevent prolonged POI. Adult patients undergoing laparoscopic colorectal surgery are randomized 1:1 to consume either concentrated beetroot juice (active intervention) or nitrate-depleted concentrated beetroot juice (placebo) during the week before their surgery. Blood, tissue and/or fecal samples are collected at specific time points pre- and/or postoperatively to study markers related to inflammation, oxidative stress and GI function. Patients are followed from the week before surgery (start of the intervention) until 3 months post-surgery. The study takes place at 5 hospitals in Flanders, Belgium.
Trial Details
NCT Number NCT05133024
Lead Sponsor University Hospital, Ghent
Collaborators: Research Foundation Flanders
Conditions
(from sponsor)		 Postoperative Ileus
Enrollment 170 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov