Clinical Trial

The Impact of Atrial Pressure Change Before and After Combined Procedure

Recruiting
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Record status
This record was last updated September 2, 2022 (before its estimated November 10, 2023 completion). Its status may not reflect the trial's current state.
Summary
One-stop procedure combining catheter ablation (CA) and left atrial appendage closure (LAAC) has been a feasible treatment for patients with atrial fibrillation at high risk of stroke and/or bleeding. Although it could achieve considerable rhythm control and stroke prophylaxis, a number of patients has experienced progressive heart failure after the procedure. Notably, previous studies indicate that both pulmonary vein isolation by CA and LAAC could significantly increase left atrial pressure, while currently no study has investigated left atrial pressure change in patients underwent combined procedure. The investigators hypothesise that combined procedure would significantly increase left atrial pressure and subsequently deteriorate cardiac function. Therefore, the investigators aim to measure the left and right atrial pressure change before and after CA and LAAC in combined procedure, and investigate the influence of the pressure change on clinical outcomes.
Protocol Amendment History 1 amendment
This ClinicalTrials.gov record has been amended once since 2021-10-21.
Status change: Not Yet Recruiting → Recruiting 2022-08-30
Trial Details
NCT Number NCT05106270
Lead Sponsor Shanghai 10th People's Hospital
Conditions Atrial Fibrillation, Heart Failure
Enrollment 100 participants
Start Date 2021-11-10
Primary Completion 2023-11-10 (estimated)
Study Completion 2027-11-10 (estimated)
Updated on ClinicalTrials.gov 2022-09-02