RCT of At-Home tDCS for Depression in Pregnancy

This is a randomized, sham-controlled trial to determine whether treatment with transcranial direct current stimulation (tDCS) is superior to a sham condition at reducing the symptoms of depression in pregnant people with moderate to severe depression. The study aims to enrol 156 participants across all sites. Data collection occurs at baseline, immediately after treatment, every 4 weeks during pregnancy and 4-, 12-, 26- and 52-weeks postpartum

NCT Number	NCT05097586
Lead Sponsor	Women's College Hospital Collaborators: Centre for Addiction and Mental Health, Sunnybrook Health Sciences Centre
Conditions	Major Depression, Pregnancy, Postpartum Depression
Enrollment	156 participants
Start Date	2021-11-08
Primary Completion	2027-03-31 (estimated)
Study Completion	2028-06-30 (estimated)
Updated on ClinicalTrials.gov	2026-08-10