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Therapeutic Plasma Exchange in Septic Shock: A Pilot Study

Study acronym: PLEXSIS
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

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  1. Primary completion date: Mar 2026 to Mar 2027
    • Study sites: 9 to 11
    • Study completion date: Dec 2026 to Dec 2027
    • Eligibility criteria expanded, about 4 words
    v4
  2. Study sites: 7 to 9v3
  3. Trial status: Not Yet Recruiting to Recruitingv2 Show 7 more changesShow less
    • Primary completion date: Dec 2023 to Mar 2026
    • Start date changed from estimate of Oct 2021 to Jun 1, 2023
    • Study sites: 0 to 7
    • Study completion date: Dec 2023 to Dec 2026
    • Eligibility criteria shortened, about 45 words
    • Secondary endpoints: details revised at 3 of 3 entries
    • Study description expanded, about 31 words
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The investigators propose to conduct a multi-center randomized pilot feasibility trial comparing therapeutic plasma exchange to standard of care in patients diagnosed with septic shock.
Trial Details
NCT Number NCT05093075
Lead Sponsor University of Manitoba
Collaborators: Canadian Institutes of Health Research (CIHR), Health Sciences Centre Foundation, Manitoba, McMaster University, University of Toronto
Conditions
(from sponsor)		 Septic Shock
Related terms Sepsis, Shock, Septic
Enrollment 80 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov