Cognition and QoL After Thyroid Surgery

The development of cognitive dysfunction can profoundly affect HR-QoL as well as the possibility of societal participation and ability to work, and thereby relevantly impacts prospects for cancer survivorship. The aim of the study is to obtain improved understanding of the scope and magnitude of objective cognitive dysfunction in DTC survivors, and its relation to subjective cognitive dysfunction, thyroid hormone levels, physical activity and HRQoL. This is done in a prospective study where patients operated for a thyroid nodule (Bethesda IV-VI, i.e., benign \[goitre with nodule and fibroadenomas\], low-risk DTC and intermediate-high risk DTC) are included and asked to serially perform online neuropsychological testing as well as to complete questionnaires related to HR-QoL, physical activity and additional psychological and physical complaints. Blood is analysed for levels of thyroid hormones and systemic inflammation.

NCT Number	NCT05088187
Lead Sponsor	Karolinska University Hospital Collaborators: The Netherlands Cancer Institute
Conditions	Thyroid Nodule, Thyroid Cancer, Cognitive Decline, Survivorship, Symptoms, Cognitive
Enrollment	320 participants
Start Date	2023-01-17
Primary Completion	2023-11-01 (estimated)
Study Completion	2026-11-01 (estimated)
Updated on ClinicalTrials.gov	2023-01-18