Iron Supplementation in Upper Non-variceal Gastrointestinal Bleeding

Anemia is a frequent complication of gastrointestinal bleeding, affecting 61% of the patients. Currently, anemia caused by gastrointestinal bleeding can be treated with iron supplementation. However, the dose and route of the administration are still a question. The FIERCE clinical trial aims to compare the effect of intravenous iron supplementation and oral iron replacement on mortality, unplanned emergency visits, and hospital readmissions in multimorbid patients with acute nonvariceal gastrointestinal bleeding.

NCT Number	NCT05060731
Lead Sponsor	University of Pecs
Conditions	GastroIntestinal Bleeding, Anemia
Enrollment	570 participants
Start Date	2025-09-01
Primary Completion	2027-12-31 (estimated)
Study Completion	2028-02-01 (estimated)
Updated on ClinicalTrials.gov	2025-03-30