Clinical Trial

Ovarian Hormone Regulation of Central and Cerebrovascular Hemodynamics (NoMEN Study)

Active, Not Recruiting Phase 4
View on ClinicalTrials.gov →
Summary
This study will evaluate changes in blood vessels around the heart (e.g., aorta and carotid arteries) and in the brain with the loss of female sex hormones (e.g., estrogen) during the menopause transition. The menopause transition is associated with declines in blood vessel function and increased risk for cardiovascular disease and Alzheimer's disease. Increasing evidence supports an early role for declines in blood vessel function and future development of Alzheimer's disease in aging men and women. This study will learn about the effects of changes in female sex hormones, such as estrogen, during the menopause transition on blood vessel around the heart and in the brain in women.
Protocol Amendment History 10 amendments
This ClinicalTrials.gov record has been amended 10 times since 2021-09-16; most recent amendment 2025-09-23.
Status change: Active, Not Recruiting → Completed 2025-08-25
Status change: Recruiting → Active, Not Recruiting 2024-03-19
Status change: Not Yet Recruiting → Recruiting 2021-11-17
Trial Details
NCT Number NCT05057546
Lead Sponsor University of Colorado, Denver
Conditions Menopause, Estrogen Deficiency, Women, Aging
Enrollment 55 participants
Start Date 2021-11-22
Primary Completion 2024-09-18 (estimated)
Study Completion 2025-07-28 (estimated)
Updated on ClinicalTrials.gov 2025-03-27