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CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke

Study acronym: COMET-AIS
StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗
Trial flagged as At Risk
Primary completion moved at least 2 years 3 months later Jul 19, 2026 → Oct 20, 2028
See other at-risk trials from University Hospital, Clermont-Ferrand

Record History

  1. Primary completion pushed from Jul 19, 2026 to Oct 20, 2028
    • Study completion pushed from Oct 19, 2026 to Oct 20, 2028
    v4
  2. Primary completion date: Jun 19, 2024 to Jul 19, 2026
    • Study completion date: Oct 19, 2024 to Oct 19, 2026
    v3
  3. Trial status: Not Yet Recruiting to Recruitingv2 Show 4 more changesShow less
    • Primary completion date: Aug 2, 2023 to Jun 19, 2024
    • Start date changed from estimate of Oct 2, 2021 to Jul 20, 2022
    • Study completion date: Nov 2, 2023 to Oct 19, 2024
    • Site details revised
  4. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process. Cerebral collateral circulation may preserve an ischemic penumbra that could recover providing timely reperfusion of the occluded vessel. Mechanical thrombectomy is the standard of care for anterior circulation large vessel reperfusion. Strategy to promote cerebral blood flow in collateral circulation before reperfusion is scarce and rely mainly on blood pressure maintenance. Carbon dioxide is a potent cerebral vasodilator that could enhance collateral circulation blood flow and cerebral protection before reperfusion. General anesthesia with endotracheal mechanical ventilation could be used for thrombectomy and give the opportunity to modulate and control carbon dioxide tension in the blood. This study will test the effect of moderate hypercapnia on penumbral collateral circulation before reperfusion during mechanical thrombectomy for anterior circulation acute ischemic stroke under general anesthesia.
Trial Details
NCT Number NCT05051397
Lead Sponsor University Hospital, Clermont-Ferrand
Conditions
(from sponsor)		 Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation, Carbon Dioxide
Related terms Ischemic Stroke
Enrollment 50 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov