CO2 Modulation in Endovascular Thrombectomy for Acute Ischemic Stroke

Acute ischemic stroke due to large vessel occlusion is responsible of cerebral blood flow impairment with a progressive and extensive ischemic process. Cerebral collateral circulation may preserve an ischemic penumbra that could recover providing timely reperfusion of the occluded vessel. Mechanical thrombectomy is the standard of care for anterior circulation large vessel reperfusion. Strategy to promote cerebral blood flow in collateral circulation before reperfusion is scarce and rely mainly on blood pressure maintenance. Carbon dioxide is a potent cerebral vasodilator that could enhance collateral circulation blood flow and cerebral protection before reperfusion. General anesthesia with endotracheal mechanical ventilation could be used for thrombectomy and give the opportunity to modulate and control carbon dioxide tension in the blood. This study will test the effect of moderate hypercapnia on penumbral collateral circulation before reperfusion during mechanical thrombectomy for anterior circulation acute ischemic stroke under general anesthesia.

NCT Number	NCT05051397
Lead Sponsor	University Hospital, Clermont-Ferrand
Conditions	Ischemic Stroke, Acute, Thrombectomy, Anesthesia, General, Cerebrovascular Circulation, Carbon Dioxide
Enrollment	50 participants
Start Date	2022-07-20
Primary Completion	2026-07-19 (estimated)
Study Completion	2026-10-19 (estimated)
Updated on ClinicalTrials.gov	2025-10-06