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Individually Targeted Neuromodulation for Contamination-based OCD

StatusRecruiting
PhaseNot applicable
Started2022-07-01
View on ClinicalTrials.gov ↗
Record status
This record was last updated March 15, 2024 (before its estimated June 30, 2024 completion). Its status may not reflect the trial's current state.

Amendment history

2025-09-03
Study Status, Study Design, Outcome Measures, Document Section, Participant Flow, Baseline Characteristics, Outcome Measures (Results), Adverse Events v6
Enrollment target50→3
Secondary endpoints3 entries, revised
Change in Functional Activation of R MFG and Brain Regions Within VAN During an RSVP Task (Expressed as a Beta Value) Following 6 Weeks of Active (cTBS/iTBS) Versus Sham TMS Change in Dimensional Yale-Brown Obsessive Compulsive Scale (D-YBOCS) Following 6 Weeks of Active (cTBS/iTBS) Versus Sham Change in Yale-Brown Obsessive Compulsive Scale (YBOCS) Following 6 Weeks of Active (cTBS/iTBS) Versus Sham TMS
Primary endpoints1 entry, revised
Change in Functional Connectivity Between R MFG and Brain Regions Within VAN (Expressed as a Z-score) Following 6 Weeks of cTBS/iTBS Versus Sham TMS
2025-06-03
Recruiting→Terminated Study Status, Study Design, Outcome Measures, Contacts/Locations, Document Section, Participant Flow, Baseline Characteristics, Outcome Measures (Results), Adverse Events, More Information v5
Trial statusRecruiting→Terminated
Reason stoppednot stated→Insufficient recruitment
Secondary endpoints3 entries, revised
Functional activationActivation of R MFG and brainBrain regionsRegions withinWithin VAN duringDuring an RSVP taskTask (expressedExpressed as a betaBeta valueValue)
Primary endpoints1 entry, revised
Functional connectivityConnectivity betweenBetween R MFG and brainBrain regionsRegions withinWithin VAN (expressedExpressed as a Z-score)
Study sitesdetails revised at 1 of 1 site
2024-03-14
Study Status v4
Re-verified, no change to tracked fields
2022-11-14
Study Status, Eligibility, Contacts/Locations v3
Eligibility criteria+40 characters
[...] ng no psychiatric medications or on a stable dose of an SSRI, clomipramine, SNRI, or clomipraminesecond generation antipsychotic for at least 84 weeks prior to enrollment. Use of PRN benzodiazepines will [...] se of exposure and response prevention (ERP) therapy within 84 weeks of enrollment (ongoing ERP will be permitted if initi [...]
2022-06-27
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v2
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2023-06-30→2024-06-30
Completion date2023-06-30→2024-06-30
Start date2022-06-01→2022-07-01
Study sitesdetails revised at 1 of 1 site
2022-04-04
Study Status v1
Start date2021-10-01→2022-06-01
2021-09-08
Original filing
Mclean Hospital
53 trials monitored
See 1 trial at risk
Patients with obsessive-compulsive disorder (OCD) experience a wide array of different types of obsessions and compulsions. However, current treatments for OCD employ a "one size fits all" approach and are used for all patients regardless of symptom type. In this project, the investigators propose to investigate whether a novel method of transcranial magnetic stimulation specifically reduces contamination/washing symptoms - one of the most common types of OCD.
Trial Details
NCT Number NCT05048251
Lead Sponsor Mclean Hospital
Collaborators: Massachusetts General Hospital
Conditions Obsessive-Compulsive Disorder
Enrollment 50 participants
Start Date 2022-07-01
Primary Completion 2024-06-30 (estimated)
Study Completion 2024-06-30 (estimated)
Updated on ClinicalTrials.gov 2024-03-15