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Optimizing Neurocognition With Whole Brain Radiation Therapy (WBRT) Using Upfront Pulsed Reduced Dose-Rate (PRDR) Technique

StatusRecruiting
PhasePhase 2
Started
View on ClinicalTrials.gov ↗

Record History

  1. Site contacts updated at 1 of 2 sitesv9
  2. Site contacts updated at 1 of 2 sitesv8
  3. Primary completion date: May 2025 to May 2028 Completion date: May 2026 to May 2029v7 Show 1 more changeShow less
    • Completion date: May 2026 to May 2029
  4. Primary completion date: May 2024 to May 2025 Completion date: May 2025 to May 2026v6 Show 1 more changeShow less
    • Completion date: May 2025 to May 2026
  5. Primary endpoints: 26 to 1 Study sites: 1 to 2 · Study description revisedv5 Show 2 more changesShow less
    • Study sites: 1 to 2
    • Study description revised

    See this version in full on ClinicalTrials.gov ↗

Show 3 earlier versionsHide 3 earlier versions
  1. Eligibility criteria expanded, about 19 words Site contact updatedv4 Show 1 more changeShow less
    • Site contact updated

    See this version in full on ClinicalTrials.gov ↗

  2. Trial status: Not Yet Recruiting to Recruiting Start date changed from estimate of Nov 2021 to Nov 17, 2021 · Site details revisedv3 Show 2 more changesShow less
    • Start date changed from estimate of Nov 2021 to Nov 17, 2021
    • Site details revised
  3. Interventions: Memantine -Twice Daily <5 CrCL (Drug), Memantine -Twice Daily ≥30 creatinine clearance. (Drug), Memantine -Twice Daily ≥5-29 CrCl (Drug)… to Memantine -Twice Daily or Extended Release (Drug), WBRT utilizing the PRDR technique (Radiation) Study title revised · Study arms: 6 to 1 · Study description expanded, about 1 wordv2 Show 3 more changesShow less
    • Study title revised
    • Study arms: 6 to 1
    • Study description expanded, about 1 word

    See this version in full on ClinicalTrials.gov ↗

  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
Study patients will receive Whole-brain radiation therapy (WBRT) - pulsed reduced dose rate (PRDR) within 14 days of registration. All patients will receive single daily fractions using 3D conformal radiotherapy. A dose of 30 Gy in 10 fractions will be delivered using the PRDR technique.
Trial Details
NCT Number NCT05045950
Lead Sponsor Medical College of Wisconsin
Conditions Brain Metastases
Enrollment 53 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov