Autoimmune Basis for Postural Tachycardia Syndrome

The purpose of this study is to test the hypothesis that an antibody-mediated autoimmune reaction will cause symptoms of autonomic dysfunction in some patients with postural tachycardia syndrome (POTS). The investigators further hypothesize that electrical stimulation of the vagus nerve will improve POTS symptoms, autoimmunity and inflammation.

NCT Number	NCT05043051
Lead Sponsor	University of Oklahoma Collaborators: National Heart, Lung, and Blood Institute (NHLBI)
Conditions	Postural Tachycardia Syndrome
Enrollment	80 participants
Start Date	2022-01-14
Primary Completion	2026-02-28 (estimated)
Study Completion	2026-07-15 (estimated)
Updated on ClinicalTrials.gov	2026-07-29