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Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients With Eosinophilic Granulomatosis With Polyangiitis (E-merge)

Study acronym: E-merge
StatusCompleted
PhasePhase 3
Started2022-05-30
View on ClinicalTrials.gov ↗

Amendment history

2026-10-02
Trial completed
Primary completion confirmed: February 2025 (last estimated November 2025)
2025-11-17
Study Identification, Study Status, Oversight, Conditions v6
Study titlerevised
Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients withWith Eosinophilic Granulomatosis withWith Polyangiitis (E-merge)
2025-01-17
Study Status v5
Re-verified, no change to tracked fields
2024-10-21
Recruiting→Active, Not Recruiting Study Identification, Study Status, Oversight, Conditions, Study Design, Contacts/Locations v4
Trial statusRecruiting→Active, Not Recruiting
Study sitesdetails revised at 1 of 1 site
Study titlerevised
Study of Mepolizumab-based Regimen Compared to Conventional Therapeutic Strategy in Patients Withwith Eosinophilic Granulomatosis Withwith Polyangiitis (E-merge)
2024-04-26
Study Status v3
Primary completion date2025-05→2025-11
Completion date2025-05→2025-11
Show 2 earlier versions
2023-10-27
Study Status v2
Re-verified, no change to tracked fields
2022-06-28
Not Yet Recruiting→Recruiting Study Status, Contacts/Locations v1
Trial statusNot Yet Recruiting→Recruiting
Primary completion date2024-12→2025-05
Completion date2024-12→2025-05
Start dateestimated 2021-12→confirmed 2022-05-30
Study sitesdetails revised at 1 of 1 site
2021-08-27
Original filing
The purpose of this study is to compare mepolizumab-based regimen to conventional therapeutic strategy for remission induction in patients with Eosinophilic Granulomatosis with Polyangiitis.
Trial Details
NCT Number NCT05030155
Lead Sponsor Assistance Publique - Hôpitaux de Paris
Collaborators: French Vasculitis Study Group, URC-CIC Paris Descartes Necker Cochin
Conditions Eosinophilic Granulomatosis With Polyangiitis
Enrollment 102 participants
Start Date 2022-05-30
Primary Completion 2025-02-21 (estimated)
Study Completion 2025-09-05 (estimated)
Updated on ClinicalTrials.gov 2026-10-01