Clinical Trial

Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria at OCT in Patients With ACS

Study acronym: INTERCLIMA
Active, Not Recruiting
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Summary
The INTERCLIMA (Interventional Strategy for Non-culprit Lesions With Major Vulnerability Criteria Identified by Optical Coherence Tomography in Patients With Acute Coronary Syndrome) is a multi-center, prospective, randomized trial of optical coherence tomography (OCT)-based versus physiology-based (i.e. fractional flow reserve\[FFR\]/instantaneous Wave-Free Ratio\[iFR\]/resting full-cycle ratio\[RFR\]) treatment of intermediate (40-70% diameter stenosis), non-culprit coronary lesions in acute coronary syndrome (ACS) patients undergoing coronary angiography. About 1420 patients with ACS will be randomized into the study at approximately 40 sites worldwide.
Protocol Amendment History 3 amendments
This ClinicalTrials.gov record has been amended 3 times since 2021-08-24; most recent amendment 2026-07-11.
Status change: Recruiting → Active, Not Recruiting 2026-07-11
Trial Details
NCT Number NCT05027984
Lead Sponsor Centro per la Lotta Contro l'Infarto - Fondazione Onlus
Collaborators: Abbott Medical Devices
Conditions Coronary Artery Disease, Coronary Disease, Ischemic Heart Disease
Enrollment 1,425 participants
Start Date 2021-06-30
Primary Completion 2028-03-31 (estimated)
Study Completion 2030-03-31 (estimated)
Updated on ClinicalTrials.gov 2026-07-14