Preventing Cardiovascular Collapse With Vasopressors During Tracheal Intubation

Tracheal intubation (TI) is associated with a high risk of adverse events in critically ill patients and peri-intubation hemodynamic collapse is the most commonly observed. The primary aim of the PREVENTION trial is to compare the effect of the pre-emptive use of noradrenaline versus no peri-intubation use of noradrenaline on incidence of cardiovascular collapse following TI in adult critically ill patients. Patients with absolute indication or contraindication to vasopressor support will be excluded from this trial. Patients will be randomized 1:1 to a continuous infusion of noradrenaline started before induction titrated according to baseline mean arterial pressure. The primary outcome will be the incidence of cardiovascular collapse. Secondary outcomes will include lowest systolic blood pressure and cardiac arrest within 30 minutes from intubation.

NCT Number	NCT05014581
Lead Sponsor	University of Turin, Italy Collaborators: Istituto Di Ricerche Farmacologiche Mario Negri
Conditions	Critical Illness, Respiratory Failure
Enrollment	420 participants
Start Date	2024-08-01
Primary Completion	2026-03 (estimated)
Study Completion	2026-04 (estimated)
Updated on ClinicalTrials.gov	2025-03-28