Clinical Trial

[C-11]NPA PET-amphetamine in Cocaine Use Disorders

Recruiting Early Phase 1
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Summary
This study uses \[11C\]NPA positron emission tomography (PET) and a d-amphetamine challenge to image amphetamine induced dopamine release in the striatum in subjects with cocaine use disorders (CUD). Amphetamine-induced dopamine release data from this study will be correlated with \[11C\]NOP-1A VT measured at baseline in the midbrain. \[11C\]NOP-1A PET data will be used from aim 1 (see, Study Record: Imaging CRF X NOP interactions in Cocaine Use Disorders)
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2021-08-13; most recent amendment 2026-07-01.
Trial Details
NCT Number NCT05011760
Lead Sponsor Rajesh Narendran
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Cocaine Use Disorder
Enrollment 30 participants
Start Date 2021-01-31
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-06