Insulin Sensitivity After Breast Cancer

Epidemiological studies have revealed that 60-80% of women with breast cancer (BC) develop metabolic disorders that are similar to those observed in conditions like type 2 diabetes. These metabolic disorders, including insulin resistance, obesity, hyperinsulinemia, and glucose intolerance, are associated with increased BC recurrence and mortality. Skeletal muscle is the major site of glucose uptake in humans. The aims of the present project are to 1) determine the involvement of insulin resistance in skeletal muscle in the metabolic disorders prevalent in BC survivors, 2) identify BC-and/or treatment-induced molecular changes in skeletal muscle from BC survivors .

NCT Number	NCT05010356
Lead Sponsor	University of Copenhagen
Conditions	Insulin Sensitivity/Resistance, Breast Cancer, Survivorship, Metabolic Disturbance
Enrollment	24 participants
Start Date	2021-08
Primary Completion	2022-12 (estimated)
Study Completion	2026-09 (estimated)
Updated on ClinicalTrials.gov	2021-08-18