Clinical Trial

Imaging CRF X NOP Interactions in CUD

Recruiting Early Phase 1
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Summary
This study uses \[11C\]NOP-1A positron emission tomography (PET) and a hydrocortisone challenge to image the interaction between nociceptive opioid peptide (NOP) receptors and cortisol/corticotrophin releasing factor (CRF) in subjects with cocaine use disorders (CUD) and matched healthy controls (HC). It will also examine whether alterations in CRF x NOP interactions predict relapse in subjects with CUD.
Protocol Amendment History 8 amendments
This ClinicalTrials.gov record has been amended 8 times since 2021-08-13; most recent amendment 2026-07-01.
Trial Details
NCT Number NCT05008146
Lead Sponsor Rajesh Narendran
Collaborators: National Institute on Drug Abuse (NIDA)
Conditions Cocaine Use Disorder
Enrollment 80 participants
Start Date 2020-12-31
Primary Completion 2028-09-01 (estimated)
Study Completion 2028-09-01 (estimated)
Updated on ClinicalTrials.gov 2026-07-06