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NCT04987775 · ClinicalTrials.gov record · last posted 2025-07-08

GWICTIC: NAC Mechanistic Study in Gulf War Veterans

Study acronym: NAC
StatusRecruiting
PhaseEarly Phase 1
Started2023-11-30
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 8, 2025 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.
from the ClinicalTrials.gov record
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.

Amendment record 11 amendments on the ClinicalTrials.gov record

This ClinicalTrials.gov record has been amended 11 times since 2021-08-02; most recent amendment 2025-07-02. DataLookout shows field-level changes from the day a trial enters its daily monitoring; earlier amendments are counted here from the ClinicalTrials.gov version history. See every version on ClinicalTrials.gov ↗

2023-11-30
Status change Not Yet Recruiting→Recruitingv7
Trial Details
NCT Number NCT04987775
Lead Sponsor Nova Southeastern University
Collaborators: RTI International, Boston University, Weill Medical College of Cornell University
Conditions Gulf War Syndrome
Enrollment 170 participants
Start Date 2023-11-30
Primary Completion 2026-04 (estimated)
Study Completion 2026-04 (estimated)
Updated on ClinicalTrials.gov 2025-07-08