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GWICTIC: NAC Mechanistic Study in Gulf War Veterans

Study acronym: NAC
StatusRecruiting
PhaseEarly Phase 1
Started
View on ClinicalTrials.gov ↗
Record status
This record was last updated July 8, 2025 (before its estimated April 2026 completion). Its status may not reflect the trial's current state.

Record History

See every version on ClinicalTrials.gov ↗

  1. Primary and study completion dates: Sep 2025 to Apr 2026v12
  2. Primary completion date: Aug 2024 to Sep 2025
    • Study completion date: Sep 2024 to Sep 2025
    • Site details revised at 1 of 7 sites
    v11
  3. Primary completion date: Jun 2024 to Aug 2024
    • Site details revised at 3 of 7 sites
    • Eligibility criteria expanded, about 3 words
    v10
  4. Site details revised at 2 of 7 sitesv9
  5. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Oct 2023 to Nov 30, 2023
    • Site details revised at 7 of 7 sites
    v8
Show 6 earlier versionsHide 6 earlier versions
  1. Start date: Jul 2023 to Oct 2023v7
  2. Start date: Mar 2023 to Jul 2023v6 Show 5 more changesShow less
    • Study sites: 6 to 7
    • Primary completion date: Jan 2024 to Jun 2024
    • Study completion date: Jan 2024 to Sep 2024
    • Secondary endpoints: 7 to 2
    • Collaborators: 4 to 3
  3. Start date: Oct 2022 to Mar 2023v5
  4. Start date: Jun 2022 to Oct 2022
    • Primary completion date: Jul 2023 to Jan 2024
    • Study completion date: Sep 2023 to Jan 2024
    v4
  5. Secondary endpoints revised (7)v3
  6. Phase: Phase 2 to Early Phase 1v2 Show 8 more changesShow less
    • Start date: Oct 2021 to Jun 2022
    • Primary endpoint revised
    • Enrollment target: 156 to 170
    • Study sites: 2 to 6
    • Eligibility criteria shortened, about 14 words
    • Secondary endpoints: 6 to 7
    • Study description shortened, about 11 words
    • Study title shortened, about 4 words
  1. Study First Submitted
  • Stopped: an ongoing trial was terminated, suspended or withdrawn.
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
This mechanistic study will test if NAC affects chronic oxidative stress and depletion of antioxidants in GWI participants. Blood specimen collection and neuroimaging will be used to determine whether NAC affects serum glutathione (GSH) concentration and oxidative stress in the CNS when compared to placebo.
Trial Details
NCT Number NCT04987775
Lead Sponsor Nova Southeastern University
Collaborators: RTI International, Boston University, Weill Medical College of Cornell University
Conditions
(from sponsor)		 Gulf War Syndrome
Related terms Persian Gulf Syndrome
Enrollment 170 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov