Clinical Trial

Using Nicotine to Reverse Age-related Auditory Processing Deficits

Study acronym: Nicotine
Recruiting
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Summary
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
Protocol Amendment History 2 changes
notable Primary completion pushed: 2026-06-30 -> 2026-12-31 2026-08-11
minor Completion pushed: 2026-06-30 -> 2026-12-31 2026-08-11
Trial Details
NCT Number NCT04971954
Lead Sponsor University of California, Irvine
Collaborators: National Institute on Aging (NIA)
Conditions Auditory Perceptual Impairment, Aging
Enrollment 48 participants
Start Date 2022-02-01
Primary Completion 2026-12-31 (estimated)
Study Completion 2026-12-31 (estimated)
Updated on ClinicalTrials.gov 2026-08-10