Using Nicotine to Reverse Age-related Auditory Processing Deficits

Study acronym: Nicotine
StatusRecruiting
PhaseNot applicable
Started

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Trial flagged as At Risk
Primary completion moved at least 6 months later Jun 30, 2026 → Dec 31, 2026
Primary endpoints added 3 → 6 primary endpoints
See other at-risk trials from University of California, Irvine

Record History

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  1. Primary endpoint(s) modified
    • Study sites: 1 to 2
    • Eligibility criteria expanded, about 9 words
    • Publications: details revised at 3 of 3 entries
  2. Primary and study completion pushed from Jun 30, 2026 to Dec 31, 2026v8
  3. Primary completion date: Jan 31, 2026 to Jun 30, 2026
    • Publications: details revised at 1 of 3 entries
    v7
  4. Site contact updatedv6
  5. Site contact updatedv5
Show 3 earlier versionsHide 3 earlier versions
  1. Re-verified, no change to tracked fieldsv4
  2. Trial status: Not Yet Recruiting to Recruiting
    • Start date changed from estimate of Dec 1, 2021 to Feb 1, 2022
    • Site details revised
    v3
  3. Start date: Aug 1, 2021 to Dec 1, 2021v2
  1. Study First Submitted
  • Notable: the trial’s plan changed such as a big move in its timeline or size, a new primary endpoint, sponsor or phase, or recruiting opened or resumed.
  • Minor: routine progress and housekeeping, such as sites added or enrollment closed.
The present study will evaluate the effects of both aging and nicotine on psychophysical tasks and electrophysiological measures. Nicotine will be administered to study participants in the form of gum that is available as an over-the-counter medication. The hypothesis is that nicotine will reverse the detrimental effects of aging on auditory processing. The proposed experiments will characterize the effects of nicotine and may eventually lead to improved treatments of hearing loss in a variety of patient populations and in healthy aging.
Trial Details
NCT Number NCT04971954
Lead Sponsor University of California, Irvine
Collaborators: National Institute on Aging (NIA)
Conditions
(from sponsor)		 Auditory Perceptual Impairment, Aging
Related terms Auditory perceptual impairment
Enrollment 48 participants
Start Date
Primary Completion (estimated)
Study Completion (estimated)
Updated on ClinicalTrials.gov